Abraham was a hundred years old and his wife Sarah was ninety years old when Isaac was born to them, at the very time God had promised Abraham.
Then God said, "Yes, but your wife Sarah will bear you a son, and you will call him Isaac. I will establish my covenant with him as an everlasting covenant for his descendants after him. (Genesis 17:19)
Isaac was Sarah's first child, though fourteen years earlier Abraham had begotten a child through Hagar, Sarah's maidservant called Ishmael. He was eight days old when Abraham circumcized him and probably about two years old when a great feast was held to celebrate his being weaned. At this feast, some rude behavior on the part of Ishmael saw Hagar and her son evicted from the household, leaving Isaac with no competitor.
The next memorable event in Isaac's life is that connected with the command God gave Abraham to offer him up as a sacrifice on a mountain in the land of Moriah as a test of his faith.
Then God said, "Take your son, your only son, Isaac, whom you love, and go to the region of Moriah. Sacrifice him there as a burnt offering on one of the mountains I will tell you about." (Genesis 22:2)
The following morning Abraham saddled his donkeys with wood for the offering and along with two servants and Isaac, made his way to Moriah. On the third day they reached their destination. Abraham built an altar of stones and wood. Then the tenderly took Isaac, tied his arms together and laid him on the alter. Summoning all his courage, he raised his knife to kill Isaac when an angel cried out to him to stop.
"Do not lay a hand on the boy," he said. "Do not do anything to him. Now I know that you fear God, because you have not withheld from me your son, your only son." (Genesis 22:12)
Abraham must have been one relieved man. Spying a ram caught by its horns in the bushes, he caught it and offered it up as a sacrifice. Then he and Isaac returned home.
When Isaac was forty years of age Rebekah was chosen for his wife. In an uncanny instance of history repeating itself, Isaac went to Gerar as a consequence of a famine, where he practised the same deception with Abimelech that his father had, telling the king that Rebekah was his sister. When the king discovered the deception, he rebuked Isaac for his prevarication, but allowed him to stay on in his country.
Isaac planted crops in that land and the same year reaped a hundredfold, because the LORD blessed him. The man became rich, and his wealth continued to grow until he became very wealthy. (Genesis 26:12-13)
It wasn't long before the Philistines began to envy him. The king was also alarmed by his prosperity and growing power and told him to move on.
He sojourned briefly in the Valley of Gerar before returning to Beersheba, where God gave him fresh assurance of covenant blessing, and where Abimelech entered into a covenant of peace with him.
After the death of his father, he took up his residence at Beer Lahai Roi, where his two sons Esau and Jacob were born. And after a final major event recorded about his life concerning the blessing of his sons Esau and Jacob - Isaac died. He was 180 years old. Esau and Jacob buried him alongside his parents in the Cave of Machpelah.