She (Leah) conceived again, and when she gave birth to a son she said, "Because the LORD heard that I am not loved, he gave me this one too." So she named him Simeon. (Genesis 29:33)
Issachar was Jacob's ninth son, born again to Leah which would make him her fifth child. The Tribe of Issachar journeyed through the wilderness, along with Judah and Zebulun, and marched on the east of the tabernacle. This tribe contained 54,400 fighting men when the census was taken at Sinai. After the entrance into the Promised Land, this tribe was one of the six which stood on Gerizim during the ceremony of the blessing and cursing.
The prophetic blessing pronounced by Jacob on Issachar is an interesting one.
Issachar is a rawboned donkey lying down between two saddlebags. When he sees how good is his resting place and how pleasant is his land, he will bend his shoulder to the burden and submit to forced labor.